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浅谈富马酸的主要作用及提取方式

ZUOZHE:admin SHIJIAN:2019-04-04 16:35

ZAIZHEIYANGJINGJIXUNMENGFAZHAN,FUMASUANDUIWOMENSHENGHUOLAISHUOJIMOSHENGYOUSHUXIDECI,TASHIYIZHONGWUSEHEYIRANDEJINGTI,WEIDAOHENXIANGSHUIGUO,NEIMEDAJIALEJIEFUMASUANDEZUOYONGYOUNAXIEMA?TIQUFENXIYOUYOUNAXIENI?KUAISUIZHEXIAOBIANYIQILAIKANXIABA。YIXIAGUANYU“QIANTANFUMASUANDEZHUYAOZUOYONGJITIQUFANGSHI”DEJIESHAO。

 

 

【富马酸的作用与救治】

 

SHINIANLAIHUOPIZHILIAOYIGANDEXINXINGKOUFUFANGAN,HEGUGEANQUANSHIYANSHICANSHUXIANGJIAOFUMASUANTINUOFUWEIZHI(TDF)YOUSUOTIGAO

 

欧冠下注平台 2018NIAN11YUE19RI,——,DEKEXUE(NASIDAKESHANGSHIDAIMA:GILD)XUANBUZHONGGUOYAOPINJIANDUGUANLIJUPIZHUNRIFUYICIDEFUMASUANBINGFENTINUOFUWEIPIAN(WEILIDE®, TAF,YIBINGFENTINUOFUWEIJI25mg)KEYONGYUZHILIAOCHENGRENHEQINGSHAONIAN(12SUIYISHANG,TIZHONGZHISHAOWEI35kg)DEMANXINGYIXINGGAN(HBV)。

 

 

欧冠下注平台 WEILIDE®SHIYIZHONGXINXINGTINUOFUWEIBAXIANGQIANTIYAOWU,YANJIUXIANSHIQILEISIYUDEWEIRUIDE®(FUMASUANTINUOFUWEIZHI/TDF,300mg)DEKANGBINGDUGONGXIAO,DANJILIANGJINWEIHOUZHEDESHIFENZHIYI。

 

SHUJUXIANSHI,YUWEIRUIDE®XIANGBI,WEILIDE®JUYOUGENGDADEXUEJIANGWENDINGXING,NENGGOUGENGYOUXIAODIJIANGTINUOFUWEICHUANDIJIGANXIBAO,YINCINENGYIGENGXIAODEJILIANGJIYAO,CONGERJIANSHAOXUEXUNHUANTINUOFUWEIDEHANLIANG。LINCHUANGSHIYANXIANSHI,YUWEIRUIDE®XIANGBI,WEILIDE®KETIGAOHEGUGESHIYANSHIANQUANCANSHU。

 

NANFANGYIKEDAXUENANFANGYIYUANHOUJINLINJIAOSHOUBIAOSHI:

 

随着韦立得®的获批,医生将可以为乙肝患者提供新的疗法。韦立得®不仅能够保持与TDF相当的抗病毒疗效,临床试验显示,患者的和骨骼安全参数也得到改善。

 

欧冠下注平台 ZAIZHONGGUO,YIGANSHIYIZHONGGAOFAXINGDECHUANRANBING,YOUYUE2000WANRENFUHEXIANYOUDEZHILIAOBIAOZHUN——ZHANQUANQIUYOUZHILIAOXUQIUDEHUANZHEZONGSHUDEJINSANFENZHIYI。MEINIAN,ZHONGGUOYUEYOU30WANRENSIYUYOUYIGANDAOZHIDEGANYINGHUA。

 

欧冠下注平台 DEKEXUESHOUXIYILIAOGUANGregg AltonBIAOSHI:

 

慢性乙型肝炎仍然是中国亟待解决的公共卫生问题,仍有许多患者需要有良好耐受性和有效性的治疗方案,尤其是在目前乙肝仍需要终生治疗的情况下,治疗方案还要同时能够抵抗耐药性。德致力于与医疗卫生政府机构、官员和相关社区,帮助中国应对乙型肝炎的挑战。

 

WEILIDE®DEHUOPIJIYULIANGXIANGGUOJISANQIYANJIU(108HAOHE110HAOYANJIU)DESHUJU,YANJIUSHEJI1632MINGCHUZHIHEJINGZHIDECHENGNIANHBeAgYINXINGHEHBeAgYANGXINGYIGANBINGDUGANRANZHE(BAOKUO334MINGZAIZHONGGUOJIESHOUZHILIAODEHUANZHE)。

 

欧冠下注平台 ZAIZONGHELIANGXIANGYANJIUJIEGUOFENXIZHONG,FUYONGWEILIDE®DEHUANZHEBIFUYONGWEIRUIDE®DEHUANZHEZAIGUGEHESHIYANSHICANSHUFANGMIANYOUSUOGAISHAN。CIWAI,ZAIJIESHOUWEIQI96ZHOUDEZHILIAOQIJIAN,WUYILIHUANZHEFASHENGTINUOFUWEINAIYAO。

 

WEILIDE®YU2016NIANHUODEYUMEIGUOSHIPINYAOPINJIANDUGUANLIJUHERIBENWEISHENGLAODONGFULIBUDEPIZHUN,2017NIANHUODEOUMENGWEIYUANHUIDEPIZHUN。

 

德公布乙型肝炎治愈研究数据

 

SHANGZHOUZAIJIUZHAOKAIDE2018NIANMEIGUOGANBINGYANJIUXUEHUINIANHUISHANG,DEKEXUEGONGBULEGS-9688DEYANJIUSHUJU,GS-9688SHIYIZHONGLINCHUANGKAIFAZHONGDEKOUFUXUANZEXINGTollYANGSHOUTI8(TLR-8)JIDONGJI,SHIDEKEXUEYIGANZHIYUXIANGMUYANJIUZHONGDEJIZHONGHUAHEWUZHIYI。YANJIUSHUJUBIAOMING,GS-9688YOUWANGBANGZHUMANXINGYIGANHUANZHESHIXIANGONGNENGXINGZHIYU,KEZUOWEIQIANZAIZHILIAOFANGANJIXUKAIFA。

 

欧冠下注平台 ZAISHOUCIRENTISHIYANDEJIANKANGZHIYUANZHEANQUANYANJIUZHONG,GS-9688ZAIDANJILIANGDIZENGZHI5HAOKESHIBIAOXIANCHULIANGHAODENAISHOUXINGHEYAOXIAOHUOXING,BAOKUOSHENGCHENGLEXITONGXINGXIBAOYINZIIL-1RAHEIL-12p40YIJIJIHUOLEBAOKUOZIRANSHASHANGXIBAOHENIANMOXIANGGUANHENGDINGTXIBAOZAINEIDEGUANJIANXIANGGUANMIANYIXIBAO。

 

ZAIJIESHOU5HAOKEHUODIYU5HAOKEJILIANGZHILIAODERENQUNZHONG,CHANGJIANDEBULIANGFANYINGYOUEXINHEOUTU。MEIYOUSHOUSHIZHECHUXIAN3JIHUOYISHANGBULIANGFANYING、SHIYANSHIBULIANGFANYINGHUOYANZHONGBULIANGFANYING。WUSHOUSHIZHEZHONGDUANZHILIAO,WUSHOUSHIZHESIWANG。

 

ZAIYIXIANGZHIZAIYANJIUGS-9688ANQUANXINGHENAISHOUXINGDE1bQIYANJIUZHONG,BINGDUXUEZHENGHEBINGDUYIZHIXINGMANXINGYIGANHUANZHEZAILIANXUSIZHOU、MEIZHOUYICIGS-9688DEZHILIAOHOU,IL-12p40HEIL-1RAXIBAOYINZIBIAOXIANCHULEJILIANGYILAIXINGHUOXING。YANJIUGUOCHENGZHONGMEIYOUCHUXIANYANZHONGBULIANGFANYING;CHANGJIANDEBULIANGFANYINGYOUTOUTONGHEEXIN。

 

JIYUZHEIXIEYANJIUSHUJU,MUQIANZHENGTONGGUOIIQIYANJIUPINGGUGS-9688YONGYUZHILIAOMANXINGYIGANHUANZHEDEKENENG。

 

【富马酸的提取分析】

 

欧冠下注平台 FUMASUANSHIYIZHONGZHONGYAODEYOUJIHUAGONGYUANLIAOHEJINGXIHUAGONGCHANPIN,GUANGFANYONGYUYIYAO、SHIPIN、HUAGONG、ZENGSUJI、TULIAO、SHUZHIDENGLINGYU。

 

ZAIFUMASUANFEIYECUIQUFUMASUANYOUJIXIANGSHI,KECAIYONGLINSUANSANDINGZHI( TBP) 、JIAJIYIDINGJIJIATONG( MIBK) 、SHUANWEICUIQUJI,BUTONGDECUIQUJIZAIGONGZUOZHONGSUOYAOQIUDEWENDU,NONGDUHEPHZHIDOUBUTONG,XIAMIANZHENDUIBUTONGCUIQUJIBUTONGCAOZUOHUANJINGZAOCHENGDECUIQUXIAOLVJIEXI。

 

 

欧冠下注平台 CICISHIYANCAIYONGLINSUANSANDINGZHI( TBP) 、JIAJIYIDINGJIJIATONG( MIBK) 、SHUANSANZHONGCUIQUJI,SHEBEICAIYONGTIANYICUIQUYANFASHENGCHANDECWL-MXILIELIXINCUIQUJIJINXINGSHIYAN。

 

ZAISHIWEN25℃XIA,DUINONGDU0. 5 g /L,YOUSHUIBIWEI1:1DEFUMASUANRONGYEJINXINGCUIQU,SHIYANDECHUSHUANZAICUIQUFUMASUANSHIDECUIQUPINGHENGFENPEIXISHUDAYULINSUANSANDINGZHI( TBP) YUJIAJIYIDINGJIJIATONG( MIBK) ,QIDUIFUMASUANCUIQULVJIAOLINGWAILIANGZHONGCUIQUJIGAO。

 

欧冠下注平台 NEIMEZAIXUANYONGYIZHONGCUIQUJIJINXINGBUTONGNONGDU、BUTONGWENDUDEFUMASUANFEISHUICUIQUSHI,HUICHANSHENGSHENMEBUTONGDEJIEGUONI?

 

一、富马酸溶液的油水比对萃取的影响

 

SHOUXIANZHENDUIRONGYEYOUSHUIBIJINXINGSHIYAN,ZAISHIWEN25. 0℃XIA,CAIYONGSHUANZUOWEICUIQUJIFENBIECEDINGYOUSHUIBIWEI 1:4、1:3、 1:2、1:1、2:1、3:1 DECUIQUTIXIDUI0. 5 g /LFUMASUANXIRONGYEJINXINGCUIQU。SHIYANFAXIAN,DANGCUIQUTIXIDEYOUSHUIBIWEI1:1SHI,CUIQUTIXIKEDEDAODEFUMASUANCUIQUXIAOGUO。

 

二、富马酸溶液初始浓度对萃取的影响

 

欧冠下注平台 ZHENDUIFUMASUANYUANLIAOYENONGDUJINXINGSHIYAN,ZAI25. 0℃,YOUSHUIBIWEI1:1DETIAOJIANXIA,BUTONGFUMASUANCHUSHINONGDU( 0. 1~0. 3 mol /L) ,YISHUANWEICUIQUJI,SHIYANJIEGUOXIANSHISUIZHEFUMASUANNONGDUDEZENGJIA,CUIQULVYECHENGSHANGSHENGQUSHI。

 

三、富马酸溶液pH值对萃取的影响

 

ZHENDUIFUMASUANRONGYEPHZHIDEDAXIAO,SHIYANBAOCHIZAISHIWEN25. 0℃,YOUSHUIBIWEI1:1DETIAOJIANXIA,DIAOJIESHUIXIANGDEpHZHI,YISHUANZUOWEICUIQUJIJINXINGSHIYAN。SHIYANJIEGUOBIAOMINGSHIYIDESUANJIANCUIQUHUANJINGSHIpHZAI1. 0~ 4. 0ZHIJIAN。

 

四、温度对萃取的影响

 

SHIYANYISHUANWEICUIQUJI,FUMASUANRONGYECHUSHINONGDUWEI0. 5 g /L,YOUSHUIBIWEI1:1,FENBIECEDINGBUTONGWENDUTIAOJIANXIA25℃、50℃、75℃、100℃DECUIQUXIAOGUO。SHIYANZHENGMINGGAOWENBULIYUFASHENGCUIQUFANYING,WENDUJIANGDIKECUJINCUIQUSHIYANDEJINXING,SUOYI,CUIQUSHIYANYIZAISHIWENXIAJINXING。

 

TONGGUOCICISHIYANBIAOMING,ZAICUIQUCAOZUOZHONG,BUTONGDECUIQUJI,BUTONGDECUIQUHUANJINGYIJIQITADEYINSUYINGXIANGDOUHUIZAOCHENGCUIQUJIEGUODEBUTONG。YINCI,ZAIJINXINGCUIQUZUOYESHI,XUYAOJINXINGXIANGGUANSHIYAN,DECHUYOULIDECUIQUFANWEIYIJICUIQUTIXI,ZHEIYANGKEYISHIXIANGAOXIAOLVCUIQU。

 

YISHANGGUANYU“FUMASUANDEZUOYONGYUJIUZHI”HE“FUMASUANDETIQUFENXI”DEJIESHAO,XIWANGNENGRANGNINLEJIE“QIANTANFUMASUANDEZHUYAOZUOYONGJITIQUFANGSHI”DAILAIBANGZHU。

上一篇:富马酸在治疗效果上的不同呈现方式及在干燥剂 下一篇:富马酸的种类分析以及其发展前景

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